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Cmax = [f ~ Dose ~ {1 - Exp(-ke ~ infT)}] / [CL ~ infT ~ {1 - Exp(-ke ~ ƒÑ)}]

Cmin = Cmax ~ Exp (-ke ~ ƒÑ)

Tinf>MIC = infT + Vd / CL ~ [ LN { (MIC - Dose / CL / infT )/ (Cmin - Dose / CL / infT) } ]

Telim>MIC = - Vd / CL ~ LN (MIC / Cmax)

%T>MIC = (Tinf >MIC + Telim>MIC) / ƒÑ ~ 100


AUC / MIC = Dose / CL / MIC

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inserted by FC2 system